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Modafinil is a prescription medication primarily used for the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). It is also sometimes used off-label for other purposes.

Here are the primary uses of modafinil:

  1. Narcolepsy: Modafinil is FDA-approved for the treatment of narcolepsy, a chronic sleep disorder characterized by excessive daytime sleepiness, sudden episodes of muscle weakness or paralysis (cataplexy), hallucinations, and sleep disturbances. Modafinil helps improve wakefulness and alertness during the day, allowing individuals with narcolepsy to better manage their symptoms and function in daily activities.

  2. Obstructive Sleep Apnea (OSA): Modafinil is sometimes prescribed off-label for the treatment of excessive daytime sleepiness in individuals with obstructive sleep apnea, a sleep disorder characterized by repeated episodes of partial or complete obstruction of the upper airway during sleep, leading to pauses in breathing and disrupted sleep patterns. Modafinil can help improve wakefulness and reduce daytime sleepiness in individuals with OSA, particularly when combined with other treatments such as continuous positive airway pressure (CPAP) therapy.

  3. Shift Work Sleep Disorder (SWSD): Modafinil is also FDA-approved for the treatment of shift work sleep disorder, a circadian rhythm sleep disorder characterized by excessive sleepiness and difficulty maintaining alertness during the night shift and/or rotating shift work schedules. Modafinil helps promote wakefulness and alertness during the night shift, allowing individuals with SWSD to better adapt to their work schedules and maintain productivity.

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